Carcinogenicity of acrylamide in B6C3F1 mice and F344/N rats from a 2-year drinking water exposure |
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| Affiliation: | 1. Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States;2. Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, AR 72079, United States;3. Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Jefferson, AR 72079, United States;4. Centro de Química Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, 1049-001 Lisboa, Portugal;1. Department of Health Toxicology, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430030, China;2. School of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China;1. National Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, Zhejiang, China;2. Department of Nutrition and Food Hygiene, School of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China;1. Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt;2. Department of Forensic medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt;3. Department of Laser Sciences and interactions, National Institute of Laser Enhanced Sciences, Cairo University, Egypt;4. Pathology Department, Animal Reproduction Research Institute, Giza, Egypt;1. Laboratory of Animal Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China;2. Institute of Animal Science, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China;1. Department of Public Health, University of Naples “Federico II”, via Sergio Pansini, 5 – 80131 Naples, Italy;2. Department of Agricultural Sciences, University of Naples “Federico II”, via Università, 100 – 80055 Portici, Naples, Italy;3. Area Dipartimentale Medicina Legale e Gestione Della Responsabilità Sanitaria Az. USL Toscana Sud Est, Siena, Arezzo, Grosseto, Italy |
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| Abstract: | Acrylamide is a component of roasted coffee and certain baked and fried carbohydrate-rich foods prepared at high temperatures. We have assessed the carcinogenicity of acrylamide in male and female B6C3F1 mice and F344/N rats administered 0, 0.0875, 0.175, 0.35, or 0.70 mM acrylamide in the drinking water ad libitum for 2 years. Acrylamide caused significant dose-related decreasing trends in the body weights of F344/N rats. Acrylamide administration resulted in significant dose-related decreasing trends in survival in both sexes of B6C3F1 mice and in female F344/N rats. Histopathological analyses indicated significant dose-related increases in Harderian gland and lung tumors in male and female B6C3F1 mice. Male B6C3F1 mice also had a significantly increased incidence of forestomach tumors, while female B6C3F1 mice had significant dose-related increases in mammary gland, ovary, and skin tumors. In male and female F344/N rats, there were significant increases in thyroid tumors. Male F344/N rats also had significant dose-related increases in testes, heart, and pancreas tumors, while female F344 rats demonstrated significant increases in clitoral gland, mammary gland, oral cavity, and skin tumors. These results, combined with previous mechanistic studies, provide strong support for the concept that acrylamide is activated to a carcinogen through metabolism to glycidamide. |
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