Protective role of phosphatidylcholine against cisplatin-induced renal toxicity and oxidative stress in rats |
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| Affiliation: | 1. Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, West Bengal, India;2. Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, West Bengal, India;1. Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, South Korea;2. Department of Biomedical Science, Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon 24252, South Korea;3. Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, South Korea;4. Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon 24289, South Korea;5. Department of Emergency Medicine, Seoul Hospital, College of Medicine, Sooncheonhyang University, Seoul 04401, South Korea;6. Department of Emergency Medicine, School of Medicine, Kangwon National University, Chuncheon 24289, South Korea;7. Department of General Surgery, School of Medicine, Kangwon National University, Chuncheon 24289, South Korea;1. Kaiser Permanente Department of Surgery, San Rafael, CA, United States;2. Marin County Department of Health and Human Services, San Rafael, CA, United States;3. Aeron Biotechnology, Hayward, CA, United States;4. Buck Institute for Research on Aging, Novato, CA, United States;1. Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan;2. Department of Medicine, Kurume University School of Medicine, Kurume, Japan |
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| Abstract: | Although cisplatin is widely used in the treatment of cancers, clinical use of cisplatin is limited due to its nephrotoxicity. Pathophysiological mechanism of cisplatin-induced renal toxicity is a complex process and has not been fully understand. Reactive oxygen species (ROS) and oxidative stress have been presumed to be involved in this damage process. Phosphatidylcholine (PC) has antioxidant effect and prevents oxidative stress. Therefore, the present study aimed to investigate potential protective effects of PC on cisplatin-induced renal damage in rat. We examined the protective effects of PC on cisplatin-induced renal damage by assessment of serum creatinine, BUN, lipid peroxidation, total glutathione, glutathione peroxidase activity, catalase activity, superoxide dismutase activity and histophathological changes. PC ameliorated cisplatin-induced increases in serum creatinine, urea and oxidative stress. PC also decreased tubular degeneration and hypertrophy of glomeruli. PC may have a protective effect against cisplatin-induced nephrotoxicity in rats via enhancing antioxidant enzyme activity. |
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| Keywords: | Cisplatin Phosphatidylcholine Renal toxicity Acute renal failure Oxidative stress |
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