人胰腺癌体外抗肿瘤药物敏感性分析研究

本文对5例胰腺癌患者的自身肿瘤组织行体外化疗药物敏感性检测,分析其实验结果与临床药物治疗的相关性。本文药敏预测提示,仅2例对氟脲嘧啶显示出很好的相关性。其余3例相关性较差。其敏感药依次是丝裂霉素、阿霉素、噻替哌。在药敏指导下化疗半年后随访,5例患者中有4例药物测定结果与临床效果一致,均已存活1年以上,治疗有效率达80％。作者认为:尤其对中晚期胰腺癌患者,在药敏指导下化疗可提高生存率。

Prediction of Chemosensitivity Test on Human Pancreatic Carcinoma Cells of Short-Term Culture in Vitro

In this paper the experimental study and clinical preliminary observation of chemosensitivity test on 5 cases of pancreatic carcinoma in vitro are reported. The major drug of clinical treatment of pancreatic carcinoma was 5-FU. The results showed only two cases had good correlativity. The results of chemosensitivity test showed that drug sensitivity inten- sity was ordinally 5-FU, MMC, ADR and TSPA. A close correlation between clinical chemotherapy treatment and chemosensitivity test in vitro was found in 4 patients out of 5. The survival time was over one year and the clinical response rate was 80%. This method could help select drug for clinical treatment and specify the application of the drug, which will surely improve the survival rate.