美罗培南治疗急性白血病粒细胞减少期并发肺部感染25例

目的:研究美罗培南治疗急性白血病粒细胞减少期并发肺部感染的疗效。方法:53例急性白血病粒细胞减少并发肺部感染的病人分为2组,亚胺培南组采用亚胺培南0．5 g,iv,gtt,q8 h,美罗培南组采用美罗培南0．5g,iv,gtt,q12 h。结果:亚胺培南组和美罗培南组总有效率分别为82％及76％,2组间比较经Ridit 分析差异无显著意义(P>0．05);2组的细菌清除率分别为93％及88％,差异无显著意义(P>0．05)。结论:美罗培南可作为急性白血病并肺部感染的单一治疗手段。

Efficacy of meropenem in treating 25 patients with secondary pulmonary infection of acute leukemia in granulocytopenia phase

AIM: To study the efficacy of meropenem in treating secondary pulmonary infection of acute leukemia (AL) with granulocytopenia. METHODS: Fifty-three AL patients with pulmonary infection in the gran-ulocytopenia phase were divided into two groups. Imipenem group were treated with imipenem 0.5 g, iv,gtt,q8 h; and meropenem group were treated with meropenem 0.5 g,iv,gtt,q!2 h. RESULTS: Total effective rates were respectively 82 % and 76 % for imipenem group and meropenem group, there was no significantly difference be-tw-een the two groups by Ridit analysis(P > 0.05). Bacteria clearance rates were respectively 93 % and 88 % for the above mentioned two groups also showing no significantly differenee(P > 0.05). CONCLUSION: Meropenem also can be used as single treatment for AL patients with pulmonary infection.