新型给药系统及其在中药制剂中的研究进展

对2000年以来的新型给药系统——缓控释给药系统、靶向给药系统、透皮给药系统、黏附给药系统、无针粉末喷射给药系统、自乳化药物传递系统等在中药制剂中的研究应用进行了综述,并介绍了国际上应用前景良好的最新给药系统——药物涂层支架、基因治疗载体系统、生物芯片、分子马达、纳米陷阱等。希望能对中药剂型改革与中药现代化提供参考。近年来,国内学者对新型给药系统在中药制剂中的应用研究作了大量卓有成效的工作,为改变中药粗放生产的现状及中药现代化进程起了巨大的推动作用。但我们的研究应用水平与国际先进水平还存在很大差距,有待取得突破性的进展。在中医药现代化的进程中,将新型给药系统用于中药剂型改革不失为一条有效途径,值得我们深入研究。

Proceedings of New Drug Delivery Systems and Their Applications in the Traditional Chinese Drugs

By referred to a lot of data, some new drug delivery systems(DDSs) including the Sustained and Controlled DDS, the Targeted DDS, the Transdermal DDS, the Bioadhensive DDS, the Powderject DDS and the Self-Emulsifying DDS and their ap plications in TCD since 2000, will be summarized and some latest DDSs in the world including drug-eluting stents, gene therapy carrier system, biological chip, biomolecular motor-powered nanodevice and nanotrap will be also introduced in this paper. The objective of this paper is to introduce the new DDSs proceedings of and their applications in the Traditional Chinese Drugs(TCDs) and to provide some references for the pharmaceutics of TCD. For several recent years, the great success have been achieved in studying the new DDS application in the change of preparation of TCD by the investigators at home, but there is a large difference between at home and at board. So it is necessary to make a greater advance. During the modernization of TCD, there is an effective way that the new drug delivery systems( DDSs) will be applied in the change of the preparation of TCD.