Toxicity of combinations of arabinosylcytosine and 3-deazauridine toward neoplastic cells in culture |
| |
| Authors: | C Mills-Yamamoto G J Lauzon A R Paterson |
| |
| Affiliation: | Cancer Research Unit (McEachern Laboratory) and Department of Biochemistry. University of Alberta, Edmonton, Alberta, Canada T6G 2H7 |
| |
| Abstract: | The antiproliferative effects of 3-deazauridine and arabinosylcytosine toward cells in culture (HeLa and RPMI 6410 lymphoblastoid cells) were potentiated when the agents were present together. The conversion of arabinosylcytosine to nucleotide metabolites in RPMI 6410 cells was greatly enhanced in the presence of deazauridine: this enhancement is thought to be the basis of the potentiation in antiproliferative activity. These drug combination effects did not occur in two RPMI 6410 sublines which were resistant to deazauridine and deficient in uridine kinase activity. |
| |
| Keywords: | DU araC araCMP araCDP araCTP the 5'-mono- di- and triphosphate esters of araC araU araUMP araU 5'-monophosphate araCDPcholine the choline ester of araCDP PEI polyethyleneimine HEPES |
| 本文献已被 ScienceDirect 等数据库收录！ |
