| 喉癌中HPV 16/18 E6蛋白的表达 |
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| 引用本文： | 胡洪义,刘钧. 喉癌中HPV 16/18 E6蛋白的表达[J]. 罕少疾病杂志, 2004, 11(3): 35-37,F002 |
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| 作者姓名： | 胡洪义 刘钧 |
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| 作者单位： | 北京大学深圳医院耳鼻咽喉科,广东,深圳,518036;北京大学深圳医院耳鼻咽喉科,广东,深圳,518036 |
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| 摘 要： | 目的检测HPV16／18E6蛋白在喉癌中的表达水平，研究其表达与临床、病理参数的关系，探讨HPV在喉癌病因学中的作用。方法选取喉癌30例，另选声带息肉30例及正常喉组织6例作为对照，采用免疫组织化学方法(S-P法)检测其HPV16／18E6蛋白的表达。结果喉癌中HPV16／18E6、凹空细胞的阳性率分别为56.7％(17／30)、46．7％(14／30)。声带息肉中凹空细胞的阳性率为40％(12／30)，HPV16／18E6为阴性。正常喉组织均为阴性。喉癌中凹空细胞表达与组织分化正相关，分化越高，阳性率越高。喉癌中HPV16／18E6表达与凹空细胞表达呈正相关，与组织分化负相关，分化越低，阳性率越高。结论HPV16、18型与喉癌的发生密切相关。
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| 关 键 词： | 喉癌 人乳头状瘤病毒(HPV) 免疫组织化学 凹空细胞 |
| 文章编号： | 1009-3257(2004)03-0005-02 |
Expression of HPV16/18 E6 in laryngeal carcinoma |
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| HU Hong-yi,LIU Jun.ENT Department,Peking University Shenzhen Hospital,Guangdong ,China[. Expression of HPV16/18 E6 in laryngeal carcinoma[J]. Journal of Rare and Uncommon Diseases, 2004, 11(3): 35-37,F002 |
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| Authors: | HU Hong-yi LIU Jun.ENT Department Peking University Shenzhen Hospital Guangdong China[ |
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| Affiliation: | HU Hong-yi,LIU Jun.ENT Department,Peking University Shenzhen Hospital,Guangdong 518036,China[ |
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| Abstract: | Objective To examine the expression of HPV16/18 E6 in laryngeal carcinomaand investigate the role of HPV in laryngeal carcinogenic progression.Methods30 specimensof primary laryngeal carcinoma were subjected to immunohistochemical analyses of HPV16/18E6. 30 cases of Vocal cord polyps and 6 cases of normal laryngeal epidermal tissue wereselected as control.ResultsThe positive rate of HPV16/18 E6,koilocyte in laryngealcarcinoma was 56.7%(17/30),46.7% (14/30) respectively. In polyps,koilocyte was obtainedin 12 cases (40%) , and HPV16/18 E6 was negative. No positive expression was found innormal laryngeal tissue.The expression of HPV16/18 E6 showed a positive correlation withkoilocyte and a negative correlation with histological differentiation in laryngeal carcinoma.Positive correlation was observed between koilocyte expression and histological differentiationin carcinoma.ConclusionHPV16/18 is an important oncogenic factor of laryngeal carcinoma.[ |
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| Keywords: | laryngeal carcinoma humanpapillomavirus(HPV) immunohistochemisty koilocyte |
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