口腔扁平苔藓与白色念珠菌感染关联性的Meta分析

目的：采用Meta分析方法评价口腔扁平苔藓（OLP）与白色念珠菌感染的关联性，为OLP的抗真菌治疗提供依据。方法：计算机检索PubMed数据库、EMBase数据库、Medline数据库、Cochrane图书馆、中国知网数据库（CNKI）、中文科技期刊数据库（VIP）和万方数字化期刊库，检索从建库至2016年12月30日所有相关文献。由2位研究者按照纳入和排除标准筛选文献、提取资料并评价质量后，采用RevMan 5.3及Stata12.0软件进行Meta分析，计算优势比（OR）和95%可信区间（95% CI）以评价关联性，采用漏斗图及Egger's法评估文献的发表偏倚。结果：本组共纳入13篇病例对照研究，其中OLP患者1073例，正常对照者766名。OLP患者白色念珠菌检出率明显高出对照组（OR_合并=2.30，95% CI：1.60~3.31，P < 0.01）。其中7篇研究对OLP患者进行临床分型，糜烂型OLP（E-OLP）患者白色念珠菌感染风险明显升高（OR=10.12，95% CI：4.05~25.28，P < 0.01）。结论：OLP与白色念珠菌感染有关，这一关联性在EA-OLP患者中尤为明显。

Meta-analysis on correlation between oral lichen planus and Candida albicans infection

Objective:To evaluate the association of oral lichen planus (OLP) with Candida albicans infection by Meta-analysis,and to provide basis for the antifungal treatment of OLP.Methods:Bibliographic searches were conducted in PubMed,EMBase,Medline,The Cochrane Library,CNKI,VIP,and Wanfang databases from inception to December 30 in 2016.The literatures were screened according to the inclusion and exclusion criteria by two reviewers independently,the methodology quality was evaluated after data abstraction,and then the RevMan 5.3 and Stata 12.0 software were used for Meta-analysis to calculate the crude odd ration (OR) and 95％ confidence intervals (95％ CI).Funnel plot and Egger's methods were used for the evaluation on the publication bias of papers.Results:Thirteen trials were included in this study.Collectively,1 073 OLP patients and 766 controls were available for analysis.The detection rate of Candida albicans in the OLP patients was significantly higher than that in healthy controls (OR:2.30,95％ CI:1.60-3.31,P＜0.01).Seven studies of these included literatures were performed on clinical typing of the OLP patients,and the risk of Candida albicans infection in the patients with erosive-atrophic OLP (E-OLP) was significantly increased (OR =10.12,95％ CI:4.05-25.28,P＜0.01).Conclusion:OLP has a clear association with Candida albicans infection,and this association is particularly significant in the E-OLP patients.