Differentiation of Mycobacterium tuberculosis and Mycobacterium bovis BCG by a polymerase chain reaction assay |
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| Authors: | B B Plikaytis K D Eisenach J T Crawford T M Shinnick |
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| Affiliation: | Division of Bacterial Diseases, Centers for Disease Control, Atlanta GA 30333. |
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| Abstract: | Mycobacterium tuberculosis and Mycobacterium bovis are closely related species which carry different numbers of the repetitive DNA element IS6110. A polymerase chain reaction assay was developed to assess the copy number of IS6110 in a strain and thereby differentiate these two important human pathogens. |
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