Complement receptor type 1 (CR1) deficiency on neutrophils in myelodysplastic syndrome |
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| Authors: | Akimichi Ohsaka Katsu Saionji Norimichi Watanabe Hironao Yokomichi Yuichi Sugahara Reizo Nagayama Jun Igari |
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| Institution: | Department of Haematology, Addenbrooke's Hospital, Cambridge;University of Cambridge Department of Haematology, MRC Centre, Cambridge |
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| Abstract: | SUMMARY. Dual-colour FISH has been used to study two patients with chronic myeloid leukaemia (CML) associated with a normal karyotype. Co-localization of signals from BCR and ABL cosmids was observed in interphase nuclei from both patients. In one patient, analysis of metaphase spreads showed that the 3'region of the ABL gene was deleted from one chromosome 9 and inserted into chromosome 22. In a second patient 5' BCR sequences were missing from one copy of chromosome 22, and co-localized with 3' ABL sequences on chromosome 9. These results demonstrate the molecular heterogeneity of Ph-negative CML. In addition, they illustrate the potential usefulness of dualcolour FISH on interphase nuclei for monitoring the response to treatment of patients with Ph-negative CML. |
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| Keywords: | CML BCR-ABL Philadephia negative FISH |
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