Cyclosporine A treatment in four cases of aplastic anemia |
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Authors: | A Porwit P Panayotides E Mansson E Ösby R Hast P Reizenstein |
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Institution: | (1) Division of Hematology, Department of Medicine, Karolinska Hospital, S-10401 Stockholm, Sweden |
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Abstract: | Summary Cyclosporine A (CyA) treatment of 4 patients with severe aplastic anemia, who were ineligible for bone marrow transplantation, was carried out for periods of between 12 weeks to 20 months. A normalization of Hb and bone marrow, together with a marked improvement in WBC and platelet counts, were observed in only one of these four patients. The remission was maintained for 20 months under continuous treatment. A relapse occurred only when the patient himself interrupted treatment. No serious side effects were observed with CyA doses of 4–10 mg/kg/daily and blood concentrations of 200–400 ng/ml. No significant changes in T helper/T suppressor ratios were noted during the course of CyA treatment. |
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Keywords: | Aplastic anemia Cyclosporine A T lymphocytes |
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