Anorexia following the intrahypothalamic administration of amylin. |
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Authors: | W T Chance A Balasubramaniam F S Zhang S J Wimalawansa J E Fischer |
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Institution: | Department of Surgery, University of Cincinnati Medical Center, OH 45267. |
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Abstract: | The intrahypothalamic injection of rat amylin reduced feeding in schedule-fed rats for eight hours. Specificity of this anorectic response was indicated by an appropriate dose-response relationship and the absence of effect of human amylin. Amylin-induced anorexia was accompanied by alterations in neurotransmitter metabolism similar to those observed in anorectic tumor-bearing rats. These results indicate that amylin may inhibit feeding by acting directly on hypothalamic neurons to alter metabolism of neurotransmitter systems known to affect feeding behavior. |
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