Mechanism of modulation of GABA-activated current by internal calcium in rat central neurons |
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| Authors: | Sergey M. Marchenko |
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| Affiliation: | A.A. Bogomoletz Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. |
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| Abstract: | GABA-activated currents in Purkinje cells isolated from rat cerebellum were investigated. Increase of intracellular Ca2+ in the physiological range of concentrations caused a decrease in GABA-activated chloride currents. This effect resulted from a decrease of both the maximal values of GABA-activated currents and possibly from the affinity of GABAA receptors. Therefore, the mechanism of Ca2+ effect on GABAA receptors in central rat neurons differs from that in bullfrog sensory neurons. |
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| Keywords: | γ -Aminobutyric acid Purkinje cell Cerebellum Ionic conductance Internal perfusion |
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