颈动脉粥样硬化、超敏C反应蛋白、纤维蛋白原与冠心病的关系

目的:探讨颈动脉粥样硬化(carotid atherosclerosis,CAS)、超敏C反应蛋白(high-sensitive C-reactive protein,hs-CRP)及纤维蛋白原(filfinogen,FIB)与冠心病的关系。方法:根据冠脉造影结果,将78例患者分为冠心病组和对照组,冠心病组根据血管受累数分为单支病变组、多支病变组。应用高频超声检测所有病例的双侧颈总动脉后壁的内-中膜厚度(intima-mediathickness,IMT)、斑块发生,并同时检测血清hs-CRP、FIB的浓度,比较两组IMT、斑块发生、hs-CRP、FIB的浓度。结果:冠心病组颈动脉后壁的平均IMT及斑块发生、hs-CRP、FIB浓度均高于对照组(P<0.05~P<0.01),三者均与冠脉病变受累支数呈正相关关系(P<0.05~P<0.01)。结论:颈动脉彩超在冠心病的判断中具有重要的临床价值,hs-CRP、FIB是参与和促进动脉硬化形成的重要因素,IMT、hs-CRP、FIB与冠脉病变受累支数均呈正相关。

Relationship between carotid atherosclerosis,high-sensitive C-reactive protein and fibrinogen in coronary heart disease

Objective ：To investigate the correlation of carotid atherosclerosis （CAS）, high-sensitive C-reactive protein （hs-CRP） and fibrinogen（FIB） in patients with coronary heart disease （CHD）. Methods： Seventy-eight patients who had received coronery artery angiography（CAG） examination were included in this study. According to the results of CAG, the patients were divided into single vessel group and multiple vessel groups. The intima media thickness（IMT） and plague of each patient was measured by ultrasound. The levels of hs-CRP and FIB were measured and compared. Results ： The levels of IMT, plagues, hs-CRP and FIB in CHD group were higher than those in negative group （P 〈 O. 05 to P 〈 O. O1 ）. CAS, hs-CRP and FIB were positively correlated with the count of coronary atheroscleroic lesions （ P 〈 0.05 to P 〈 0.01 ）. Conclusions： Carotid ultrasounic examination could help to predict the presence of coronary artery disease. The levels of hs-CRP and FIB play an important role in the initiation and progression of CHD. The IMT,hs-CRP and FIB have positive correlation with the count of coronary atheroscleroic lesions.