| 铁离子在铜绿假单胞菌生物被膜形成中的作用 |
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| 引用本文： | 蔡芸,倪淑欣,梁蓓蓓,安毛毛,王睿. 铁离子在铜绿假单胞菌生物被膜形成中的作用[J]. 中国临床药理学与治疗学, 2007, 12(8): 861-864 |
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| 作者姓名： | 蔡芸 倪淑欣 梁蓓蓓 安毛毛 王睿 |
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| 作者单位： | 解放军总医院临床药理研究室,北京,100853 |
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| 摘 要： | 铜绿假单胞菌由于形成生物被膜引发的难治性感染已成为医院亟待解决的问题之一。本文综述了近期关于铁离子与生物被膜形成的相关性的研究报道,从细菌吸附、小集落的形成、集落发育成熟,到最后解吸附四个过程阐述了铁离子可能产生的影响。并探讨了对临床应用抗生物被膜局部铁喷雾或者螯合剂治疗的前景。
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| 关 键 词： | 生物被膜 铜绿假单胞菌 铁离子 |
| 文章编号： | 1009-2501（2007）08-0861-04 |
| 修稿时间： | 2007-04-06 |
Role of iron in pseudomonas aeruginosa biofilm formation |
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| CAI Yun,NI Shu-xin,LIANG Bei-bei,AN Mao-mao,WANG Rui. Role of iron in pseudomonas aeruginosa biofilm formation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(8): 861-864 |
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| Authors: | CAI Yun NI Shu-xin LIANG Bei-bei AN Mao-mao WANG Rui |
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| Affiliation: | Department of Clinical Pharmacology, PIA General Hospital, Beijing 100853, China |
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| Abstract: | The infection caused by pseudomonas aeruginosa biofilm has becoming one of the most urgent problems in hospital.Recent reports of possible mechanism of iron in biofilm formation were reviewed in this paper.The possible effects of iron on adsorption,microcolony formation,mature of colony and desorb were explained,and the prospect of clinical use of local iron or chelator spray was also reviewed here. |
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| Keywords: | biofilm pseudomonas aeruginosa iron |
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