消炎痛对中晚期原发性肝癌病人NK细胞及T淋巴细胞亚群的影响

观察中晚期原发性肝癌病人在口服呋喃氟尿嘧啶的基础上加用消炎痛 (吲哚美辛 ) (治疗组 )和不加用消炎痛 (对照组 )外周血自然杀伤 (NK)细胞及T淋巴细胞亚群的变化。结果发现 :治疗组治疗后NK细胞活性较治疗前及较对照组治疗后显著提高 (P <0 .0 5 ,P <0 .0 1) ,而T淋巴细胞亚群的变化差异无显著性。提示消炎痛能增强中晚期原发性肝癌NK细胞的活性

Effect of indomethacin on natural killer(NK) cell and T lymphocyte subsets from patients with hepatocellular carcinoma

Twenty one patients with advanced hepatocellular carcinoma were randomly divided into two groups. They were orally given tegafur 200?mg three times a day with(Group Ⅰ,n=11) or without(Group Ⅱ,n=10) indomethacin 25?mg three times a day for 7 days. Before and after the therapies the NK cell and T lymphocyte subset activity in peripheral blood were measured. The results showed that NK cell activity in Group Ⅰ was significantly higher than that in Group Ⅱ(P<0.01) and that before the treatment as well(P<0.05). T lymphocyte subsets had no significant difference between the two groups and before or after the therapy. It is suggested that the indomethacin might improve the NK activity of the patients with advanced hepatocellular carcinoma.