Effects of isosorbide dinitrate on thromboxane A2 synthesis in carbon dioxide exposed platelets |
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Authors: | N Ishikawa M Kainuma K Taki I Ichimura |
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Affiliation: | Department of Pharmacology, Nagoya University School of Medicine, Japan. |
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Abstract: | Isosorbide dinitrate (Nitorol R, 100 nmol/l) blocked an increase in thromboxane B2 concentration in human platelet-rich plasma caused by exposure to high CO2 tension, in the presence of arachidonic acid. Thromboxane B2 concentrations obtained at 1 or 2 mmol/l or arachidonic acid were not influenced by isosorbide dinitrate at low CO2 tension. Inhibitory action of isosorbide dinitrate on the thromboxane A2 synthesis appears to have a close relation to the site of CO2 action. |
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