Aggression in humans correlates with cerebrospinal fluid amine metabolites. |
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| Authors: | G L Brown F K Goodwin J C Ballenger P F Goyer L F Major |
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| Institution: | 1. Gerald L. Brown, M.D., is Staff Psychiatrist, Unit on Childhood Mental Illness, Biological Psychiatry Branch, (BPB), Bethesda, MD, USA;2. Frederick K. Goodwin, M.D., is Chief, Clinical Psychobiological Branch, Bethesda, MD, USA;3. James C. Ballenger, M.D., is Clinical Associate, Section on Psychobiology, BPB, Bethesda, MD, USA;4. Peter F. Goyer, M.D., is Clinical Associate, Unit on Childhood Mental Illness, BPB, Bethesda, MD, USA;5. Leslie F. Major, M.D., is Clinical Associate, Laboratory of Clinical Neuropharmacology, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA |
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| Abstract: | Cerebrospinal fluid of the major central metabolites of serotonin (5HT), norepinephrine (NE), and dopamine (DA)--5-hydroxyindoleacetic acid (5HIAA), 3-methoxy-4-hydroxy=phenylglycol (MHPG), and homovanillic acid (HVA), respectively--were studied in a group of 26 age-similar military men with no history of major psychiatric illness, but with various personality disorders and difficulties adjusting to military life. Independently scored history of aggressive behavior showed a significant negative correlation with 5HIAA (r = -0.78) and a significant positive correlation with MHPG (r = 0.64). |
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| Keywords: | Aggression CSF 5HIAA MHPG |
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