广西桂林市10岁以下儿童麻疹抗体水平分析

目的掌握10岁以下儿童麻疹抗体水平,为麻疹防控提供科学依据。方法用分层抽样方法随机抽取488名6个年龄组的婴幼儿,采用酶联免疫吸附试验(ELISA)检测麻疹IgG抗体,结合免疫史对不同人群麻疹抗体进行分析。结果 10岁以下儿童麻疹IgG阳性率为84.51%,抗体几何平均滴度(GMT)为1∶708;6岁组和18月龄组阳性率最高,分别达到90.48%和89.47%,<8月龄组阳性率最低,为56.34%,GMT较高的是18月龄组,为1∶978,较低的是<8月龄组,为1∶370,接种第1剂麻疹IgG抗体阳性率为76.42%,GMT为1∶484,接种第2剂麻疹IgG抗体阳性率达到88.12%,GMT达到1∶839,男性与女性麻疹IgG抗体水平无差异。结论 <8月龄婴幼儿麻疹抗体水平偏低,是目前防治麻疹的关键群体,8月龄至10岁儿童具有较好的免疫屏障。应加强血清学监测,根据监测结果适时开展强化免疫。

Measles antibody level in children under 10 years old in Guilin

Objective To understand the measles antibody level in the children under 10 years old in Guilin and provide evidence for measles prevention and control. Methods Serum samples were collected from 488 children in 6 age groups by stratified random sampling to detect measles IgG antibody by ELISA, the antibody level in different age groups were compared. Results The positive rate of measles antibody in the children under 10 years old was 84. 51% and the geometric mean titer （GMT） was 1： 708. The positive rates in the age groups of 6 years and 18 months were highest （90.48% and 89.47% ）. The positive rate in age group of 〈 8 months was lowest （56. 34% ）. The highest GMT was 1：978 in age group of 18 months, and the lowest GMT was 1：370 in age group of〈8 months. The positive rate after the first measles immunization was 76. 42%, the GMT was 1： 484. The positive rate after the second measles immunization was 88.12%, the GMT was 1 ： 839. There was no significant difference on measles IgG antibody level between boys and girls. Conclusion Positive rate of measles antibody is not high in children aged less than 8 months in Guilin, sporadic measles case might occur among them. The children from 8 mouths to 10 years old are well immunized. It is necessary to strengthen measles immunization according to the result of surveillance.