| NOD1和NOD2基因多态性与胃癌遗传易感性的研究 |
| |
| 引用本文： | 路滟,徐耀初,沈洪兵.NOD1和NOD2基因多态性与胃癌遗传易感性的研究[J].疾病控制杂志,2011,15(9):735-739. |
| |
| 作者姓名： | 路滟 徐耀初 沈洪兵 |
| |
| 作者单位： | 1. 深圳市疾病预防控制中心传染病防制科,广东,深圳,518055
2. 南京医科大学公共卫生学院,江苏,南京,210029 |
| |
| 基金项目： | 国家自然科学基金(30700684) |
| |
| 摘 要： | 目的探索NOD1和NOD2功能性单核苷酸多态性(single nucleotide polymorphisms,SNPs)位点与胃癌易感性的关系。方法采用病例对照研究设计,比较病例组与对照组先天免疫反应信号通路相关基因NOD1和NOD2功能SNPs的频率差异。结果携带NOD1 rs2906766 C等位基因,可显著增加60岁及以上的个体(调整OR=1.30,95%CI=1.02~1.65)、吸烟者(调整OR=1.38,95%CI=1.05~1.82)和H.pylori阴性者(调整OR=1.36,95%CI=1.03~1.79)发生胃癌的风险,但没有发现NOD2 rs3135500位点A>G的改变与中国人群胃癌的发生有关联。结论 NOD1基因rs2906766位点C>T的改变与中国人群胃癌的遗传易感性有关联,但需要在更大样本中验证这一结果,并开展功能学研究以揭示其潜在的生物学机制。
|
| 关 键 词： | NOD1信号接头蛋白质 NOD2信号接头蛋白质 胃肿瘤 多态现象 遗传 |
Association of variants of NOD1 and NOD2 genes with susceptibility to gastric cancer in a Chinese population |
| |
| LU Yan,XU Yao-chu,SHEN Hong-bing.Association of variants of NOD1 and NOD2 genes with susceptibility to gastric cancer in a Chinese population[J].Chinese Journal of Disease Control and Prevention,2011,15(9):735-739. |
| |
| Authors: | LU Yan XU Yao-chu SHEN Hong-bing |
| |
| Institution: | LU Yan1,XU Yao-chu2,SHEN Hong-bing2.1.Department of Infectious Disease,Shenzhen Center for Disease Control and Prevention,Shenzhen 518055,China,2.School of Public Health,Nanjing Medical University,Nanjing 210029 |
| |
| Abstract: | Objective To test the hypotheses that the genetic variants of NOD1and NOD2 were associated with H.pylori-related gastric cancer susceptibility.Methods A case-control study of 1 053 patients with incident gastric cancer and 1 100 cancer-free controls in a high-risk Chinese Han population was performed to detect the associations of functional polymorphisms in NOD1and NOD2 with gastric cancer risk in Chinese population,and to clarify the mechanism and risk genotypes of gastric cancer.Results Stratified analyse... |
| |
| Keywords: | NOD1 signaling adaptor protein NOD2 signaling adaptor protein Stomach neoplasms Polymorphism genetic |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
