鼠疫与假结核耶尔森菌基因组比较分析

为了在流行静息期间建立鼠疫监测,比较自网上下载的10株鼠疫菌及3株假结核菌的全基因组序列。发现依照鼠疫菌CO92株划分的68个"板块",67个在假结核菌中完整或大部出现,确定了这些板块在假结核菌基因组中的连接顺序。确定了假结核菌具有与鼠疫菌同样的7拷贝rRNA基因簇,并由此引起最初的基因组重排。假结核菌与鼠疫菌分野前已在16个位置插入了4种插入序列,这些插入序列在假结核菌中尚未引起重排。确定了20处鼠疫菌特有的"疫岛(PeI)"与39处假结核菌特有的"假岛(PsI)"序列,这些序列可在监测中遇到非典型菌株时,用于鉴别鼠疫菌与假结核菌。

Comparative analys is of Yersinia pestis and Yersinia pseudotuberculosis chromosomes

For plague surveillance in the silence periods,the whole genome sequences of 10 Yersinia pestis strains and 3 Yersinia pseudotuberculosis strains downloaded from Internet were compared.In the 68 Y.pestis Tectonics divided according to CO92 chromosome sequence,67 appeared in Y.paeudotuberculosis genomes in whole or in most part,the arrangement of these tectonics were determined.Y.pseudotuberculosis has the same 7 copies of rRNA gene clusters as Y.pestis,and they caused the earliest genome rearrangement in Y....