江西省南昌市孕妇及婴儿麻疹抗体水平监测分析

目的 了解江西省南昌市新生儿和母亲配对麻疹抗体水平及0~8月龄婴幼儿麻疹抗体水平变化情况。 方法 应用酶联免疫吸附试验(ELISA)法对婴幼儿及其母亲进行麻疹抗体IgG水平测定,几何抗体平均滴度(GMT)1 ∶ 200为阳性,GMT1 ∶ 800为有保护性。 结果 新生儿脐血与母血抗体GMT分别为1 ∶ 408、1 ∶ 483,GMT接近一致, 母亲抗体阳性率为85.71 %,婴儿抗体阳性率为 77.14%,差异无统计学意义 (2=1.70, P0.05)。随时间推移, 母传抗体GMT随月龄增大而逐渐下降, GMT由新生儿的1 ∶ 408降至8月龄的1 ∶ 112,GMT多未达保护水平。6~8月龄婴儿抗体水平下降明显,保护性抗体水平降至30%以下。 结论 建议对育龄妇女进行麻疹疫苗接种,提高婴儿麻疹疫苗首针及时率,降低麻疹发病率,以尽快达到消除麻疹的目的。

Surveillance of measles antibody levels in infants and their mothers in Nanchang city,Jiangxi province

Objective To understand the measles antibody lrevls in neonates and their mothers as well as the change in measles antibody level in infants during the first 8 months life.Methods Measles antibody IgG levels were detected among neonates and their mothers with enzyme linked immunosorbent assay（ELISA）.The geometric mean titer（GMT） ≥ 1∶200 was considered as positive,GNT ≥ 1∶800 was protective.Results The GMTs in umbilical cord blood and maternal blood were similar,which were 1∶408 and 1∶483 respectively The maternal antibody positive rate was 85.71% and the neonate antibody positive rate was 77.14%,the difference was without statistically significance（χ2= 1.70,P0.05）.The maternal antibody GMT in infants declined gradually with the increase of age,which declined from 1∶408 at birth to 1∶112 at age of 8 months（a level without protective importance）.The maternal antibody GMT declined rapidly in infants aged 6-8 months,resulting in a30% protection level.Conclusion It is suggested to conduct measles vaccination for women of childbearing age,increase the timely vaccination rate of the first measles vaccine dose in infants in order to reduce the incidence of measles and achieve the goal of eliminating measles.