| 山西地区血管紧张素原基因和α-内收蛋白基因多态性与原发性高血压的相关性研究 |
| |
| 引用本文： | 李哲,王丹,李翠丽,才丽娜,率中泰,杨瑾,张玲,兰文燕. 山西地区血管紧张素原基因和α-内收蛋白基因多态性与原发性高血压的相关性研究[J]. 疾病控制杂志, 2011, 15(9): 740-744 |
| |
| 作者姓名： | 李哲 王丹 李翠丽 才丽娜 率中泰 杨瑾 张玲 兰文燕 |
| |
| 作者单位： | 1. 山西医科大学第一医院心内科,山西太原,030001
2. 山西医科大学公共卫生学院,山西太原,030001 |
| |
| 基金项目： | 山西省科技攻关项目(20080312018) |
| |
| 摘 要： | 目的调查山西地区血管紧张素原(angiotensinogen,AGT)和α-内收蛋白(alpha-aduction,ADD1)基因多态性与原发性高血压(essential hypertension,EH)的关系。方法采用病例对照研究,用诱变分离聚合酶链反应(mutagenically separated polymerase chain reactions,MS-PCR)检测山西地区EH患者299例(病例组)和血压正常者218例(对照组)的AGT基因M235T多态性和ADD1基因Gly460Trp多态性。结果病例组AGT基因的TT基因型分布与对照组差异有统计学意义(P<0.001),但病例组T等位基因频率(0.426)与对照组(0.378)相比,差异无统计学意义(P=0.121)。病例组ADD1基因型分布和等位基因频率与对照组相比,差异均无统计学意义(P分别为0.306和0.072)。TT+TT联合基因型患EH的危险度增加(MT+GG:OR=0.410,P=0.041;MT+GT:OR=0.364,P=0.020;MT+TT:OR=0.262,P=0.002)。Logistic回归分析提示,AGT基因的TT基...
|
| 关 键 词： | 高血压 基因型 病例对照研究 |
Association study of genetic polymorphisms of alpha-adducin and angiotensinogen with essential hypertension in Shanxi population |
| |
| LI Zhe,WANG Dan,LI Cui-li,CAI Li-na,SHUAI Zhong-tai,YANG Jin,ZHANG Ling,LAN Wen-yan. Association study of genetic polymorphisms of alpha-adducin and angiotensinogen with essential hypertension in Shanxi population[J]. Chinese Journal of Disease Control and Prevention, 2011, 15(9): 740-744 |
| |
| Authors: | LI Zhe WANG Dan LI Cui-li CAI Li-na SHUAI Zhong-tai YANG Jin ZHANG Ling LAN Wen-yan |
| |
| Affiliation: | LI Zhe1,WANG Dan1,LI Cui-li1,CAI Li-na1,SHUAI Zhong-tai1,YANG Jin2,ZHANG Ling2,LAN Wen-yan1.1.Department of Cardiology,First Hospital of Shanxi Medical University,Taiyuan 030001,China,2.School of Public Health,Shanxi Medical University |
| |
| Abstract: | Objective This case-control study was designed to investigate the association between angiotensinogen gene polymorphisms and alpha-adducin polymorphisms and essential hypertension(EH).Methods A case-control study was conducted using performed mutagenically separated polymerase chain reactions(MS-PCR) techniques to explore the AGT gene M235T polymorphisms and the ADD1 gene Gly460Trp polymorphisms in 299 EH and 218 normotensives(NT) of Shanxi Province.Results The genotypes distribution of TT in EH cases was s... |
| |
| Keywords: | Hypertension Genotype Case-control studies |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
