Effect of NO synthase inhibitor 2-amino-5,6-dihydro- 4H-1,3-thiazine on endotoxin-induced changes in hemodynamic parameters and respiration in rats |
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| Authors: | S. Ya. Proskuryakov M. V. Filimonova Yu. G. Verkhovskii A. G. Konoplyannikov A. A. Mandrugin V. M. Fedoseev V. G. Skvortsov |
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| Affiliation: | (1) Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk;(2) Chemical Department, M. V. Lomonosov Moscow State University, Russia |
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| Abstract: | We studied the effect of NO synthase inhibitor 2-amino-5,6-dihydro-4H-1,3-thiazine (2-ADT) on the cardiovascular system in rats with endotoxic shock. Blood pressure, heart rate, and respiratory rate were recorded. E. coli lipopolysaccharide decreased blood pressure and heart rate. 2-ADT in a dose of 5 mg/kg normalized these hemodynamic parameters. The normalizing effect of 2-ADT decreased with increasing the dose of this preparation. 2-ADT in high doses (10, 20, and 30 mg/kg) and repeated injections of the preparation caused death of experimental animals.Translated from Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 138, No. 10, pp. 446–449, October, 2004 |
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| Keywords: | NO synthase inhibitor septic shock blood pressure heart rate respiratory frequency |
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