早期肠内营养对高血压性颅内出血患者感染风险的影响

目的:探讨早期肠内营养对高血压性颅内出血患者感染风险的影响。方法:回顾性收集高血压性颅内出血患者142例,根据患者肠内营养开始时间,将患者分为早期肠内营养组(肠内营养开始时间≤48 h)和晚期肠内营养组(肠内营养开始时间>48 h)。主要观察指标为入院后院内死亡率、住院时间、颅内感染、泌尿系统感染、败血症、肺炎、总感染率、格拉斯哥昏迷评分(Glasgow Coma score,GCS)。结果:与晚期肠内营养组比较,早期肠内营养组患者泌尿系统感染率显著降低(2.47%vs.12.90%,P=0.036);总感染率显著降低(7.41%vs.37.10%,P=0.000);住院时间显著缩短(28.85±8.49)vs.(35.83±11.82)]d,P=0.018)。两组患者颅内感染、肺炎与败血症发生率、死亡率和入院30 d时GCS评分差异均无统计学意义(P均>0.05)。结论:早期肠内营养有助于降低高血压性颅内出血患者感染风险,缩短患者住院时间。

The effect of early enteral nutrition on the risk of infection in patients with hypertensive intracerebral hemorrhage

Objective:To discuss the effect of early enteral nutrition on the risk of infection in patients with hypertensive intracerebral hemorrhage.Methods:142 cases of patients with hypertensive cerebral hemorrhage were enrolled in this retrospective study.According to the starting time of the enteral nutrition,all patients were divided into early enteral nutrition group (enteral nutrition starting time ≤48 hours) and late enteral nutrition group (enteral nutrition starting time ＞ 48 hours).The main outcome measures were hospital mortality,hospital stay,intracranial infection,urinary system infection,sepsis,pneumonia,total infection rate,Glasgow Coma Score (GCS).Results:Compared with the late enteral nutrition group,the urinary tract infection rate of the early enteral nutrition group was significantly lower (2.47％ vs.12.90％,P =0.036),the total infection rate was significantly lower (7.41％ vs.37.10％,P =0.000),and the length of hospital stay in the early enteral nutrition group was significantly shorter (28.85 ± 8.49 vs.35.83 ± 11.82 d,P =0.018).There was no significant difference in the intracranial infection,pneumonia,incidence of sepsis,hospital mortality,GCS score at 30 days after admission between the two groups (P ＞ 0.05).Conclusion:Early enteral nutrition can help to reduce the risk of infection of patients with hypertensive intracranial hemorrhage,shorten length of hospital stay.