氨甲环酸在降低全膝关节置换术围手术期出血量的应用

目的:研究分析氨甲环酸在降低全膝关节置换术围手术期出血量的临床应用效果。方法:选取本院接受全膝关节置换术的146例患者作为本次研究对象,根据抽签方式随机分为观察组和对照组,每组各73例。观察组在术中给予氨甲环酸静脉滴注治疗;对照组在全膝关节置换术中未采取任何措施。比较两组患者的术中出血量、术后引流量、总失血量以及手术前、后血红蛋白、红细胞以及D-二聚体指标水平。结果:同对照组相比,观察组患者的术中出血量、术后引流量以及总失血量明显降低,差异有统计学意义(P<0.05);两组患者术后的血红蛋白与红细胞指标水平均有明显降低,且观察组患者的指标降低程度低于对照组,差异有统计学意义(P<0.05);两组患者术后血清中D-二聚体指标均有显著升高,且对照组升高幅度高于观察组,差异有统计学意义(P<0.05)。结论:在全膝关节置换术中静脉滴注氨甲环酸能够有效降低围手术期的引流量与出血量,改善患者体内血红蛋白、红细胞以及D-二聚体的指标水平,临床应用效果明显,值得积极应用和推广。

Application of tranexamic acid on reducing perioperative bleeding volume in total knee arthroplasty

Objective:To study the clinical effect of tranexamic acid on reducing perioperative bleeding volume in total knee arthroplasty.Methods:146 cases of patients received total knee arthroplasty in our hospital were selected as the subjects.All patients were randomly divided into two groups according to the method of lottery,73 cases in each group.The patients in the observation group were treated with intravenous infusion of tranexamic acid in total knee arthroplasty,and the control group did not take any measures in total knee arthroplasty.The intraoperative blood loss,postoperative drainage,total blood loss,preoperative and postoperative hemoglobin,erythrocyte and D-dimer index levels were compared between in the two groups.Results:Compared with the control group,the intraoperative blood loss,postoperative drainage volume and total blood loss were significantly decreased in the observation group,the differences were statistically significant(P<0.05).After operation,the levels of hemoglobin and erythrocyte were significantly lower in the two groups,and the level of the index in the observation group was lower than that in the control group (P<0.05).The serum D-dimer index in the two groups was significantly higher after operation,and the index in the control group increased higher than that in the observation group,the difference was statistically significant (P<0.05).Conclusion:The intravenous infusion of tranexamic acid in total knee arthroplasty can effectively reduce the perioperative drainage and bleeding volume,improve the levels of hemoglobin,erythrocyte and D-dimer in patients,the clinical effect is obvious,it is worthy of active application and promotion.