| miRNA-210在痴呆中的调控作用及机制 |
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| 引用本文： | 黄菁菁,燕兰云,余真,冯美江,鲁翔.miRNA-210在痴呆中的调控作用及机制[J].川北医学院学报,2017,32(3):352-354. |
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| 作者姓名： | 黄菁菁 燕兰云 余真 冯美江 鲁翔 |
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| 作者单位： | 南京医科大学第二附属医院老年科,江苏 南京,210011;南京医科大学第一附属医院神经内科,江苏 南京,210029;南京医科大学附属逸夫医院老年科,江苏 南京,211166 |
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| 基金项目： | 南京医科大学科技发展基金重点资助项目 |
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| 摘 要： | 目的:观察miRNA-210在痴呆或严重认知功能障碍老年患者血浆中的表达变化,探讨miRNA-210对老年痴呆患者的临床意义。方法:利用miRNA芯片检测老年患者(有无痴呆或严重认知功能障碍)血浆中miRNA-210水平变化。结果:痴呆或严重认知功能障碍的老年患者血浆中miRNA-210的表达水平明显高于无痴呆或严重认知功能障碍的老年患者。结论:miRNA-210在痴呆或严重认知功能障碍的发生发展过程中可能起着重要调控作用,可进一步深入研究其内在机制。
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| 关 键 词： | 痴呆 严重认知功能障碍 miRNA |
Effects and mechanism of miRNA-210 in plasma of elderly patients with dementia |
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| HUANG Jing-jing,YAN Lan-yun,YU Zhen,FENG Mei-jiang,LU Xiang.Effects and mechanism of miRNA-210 in plasma of elderly patients with dementia[J].Journal of North Sichuan Medical College,2017,32(3):352-354. |
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| Authors: | HUANG Jing-jing YAN Lan-yun YU Zhen FENG Mei-jiang LU Xiang |
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| Abstract: | Objective:Investigate the expression change of miRNA-210 in the plasma of elderly patients with dementia or severe cognitive impairment,and explore the clinical significance of miRNA-210.Methods:MiRNA-chips were used to detect changes in plasma miRNA-210 levels in elderly patients (with or without dementia or severe cognitive impairment).Results:The expression of miRNA-210 in the plasma of elderly patients with dementia or severe cognitive impairment was significantly higher than that in elderly patients without dementia or severe cognitive impairment.Conclusion:MiRNA-210 may play an important regulatory role in the development of dementia or severe cognitive impairment,and further study its intrinsic mechanism. |
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| Keywords: | Dementia Severe cognitive impairment miRNA |
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