| 细胞色素P450与肺癌关系的研究进展 |
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| 引用本文： | 于庆忠,韩金祥,高雪芹,潘继红. 细胞色素P450与肺癌关系的研究进展[J]. 医学分子生物学杂志, 2006, 3(2): 153-155 |
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| 作者姓名： | 于庆忠 韩金祥 高雪芹 潘继红 |
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| 作者单位： | 山东省医药生物技术研究中心,国家卫生部生物技术药物重点实验室,济南市,250062 |
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| 摘 要： | 细胞色素P450(CYP450)属血红蛋白类酶,是微粒体混合功能氧化酶系中最重要的一族氧化酶,分布在生物体内的各种器官组织,其作用底物非常广泛,参与机体内大部分外源性、内源性致癌物质以及抗癌药物的代谢。不同的CYP450分别代谢不同的致癌物质以及抗癌药物。现已证实CYP450家族中许多酶都具有基因多态性,其多态性在人群中的分布与多种肿瘤的易感性以及抗肿瘤药物的代谢密切相关。
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| 关 键 词： | 细胞色素P450 肺癌 相关性 |
| 修稿时间： | 2005-08-23 |
Advances in the Research of the Correlation between CYP450 and Lung Cancer |
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| YU Qingzhong,HAN Jinxiang,GAO Xueqin,PAN Jihong. Advances in the Research of the Correlation between CYP450 and Lung Cancer[J]. Journal of Medical Molecular Biology, 2006, 3(2): 153-155 |
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| Authors: | YU Qingzhong HAN Jinxiang GAO Xueqin PAN Jihong |
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| Abstract: | Cytochrome P450(CYP450) is a kind of enzyme which belongs to hemoglobin.It is the most important oxidase of the microsomal mixed-function oxidase,and is distributed in a variety of tissues of organisms.Its substrate is extensively found,so it is involved in a good many metabolic events of the exogenous and endogenous carcinogens and anticancer drugs.Different CYP450 can metabolize different carcinogens and anticancer drugs.It has now been confirmed that there are many genetic polymorphisms in the CYP450 Family, and the distribution of the polymorphism is correlated to the susceptibility to lung cancer and the metabolism of the anti-tumor drugs. |
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| Keywords: | cytochromeP450 lung cancer correlation |
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