麝香保心丸对颈动脉粥样硬化斑块的影响

目的 探讨麝香保心丸对颈动脉粥样硬化的治疗作用。方法 41例颈动脉粥样硬化患者，随机分为治疗组与空白对照组。治疗组31例给予麝香保心丸加西医常规治疗；对照组10例予西医常规治疗。两组患者均连续用药6个月。观察两组颈动脉粥样硬化斑块、C-反应蛋白（CRP）、纤维蛋白原（FIB）、D-二聚体、血脂等变化情况。结果 治疗组治疗后颈动脉平均斑块数、斑块总积分、斑块面积、CRP、FIB、D-二聚体较治疗前降低，差异有显著性（P〈0．05或P〈0．01），并且低于对照组治疗后（P〈0．05）。治疗期间两组均无严重不良反应出现。结论 麝香保心丸可作为治疗颈动脉粥样硬化的一种有效而安全的药物。

Effects of Shexiang Baoxin Pill on Carotid Atheromatous Plaque

ObjectiveTo study the effects of Shexiang Baoxin Pill (SBP) in treating carotid atherosclerosis (CAS). MethodsForty-one CAS patients were randomly assigned to 2 groups, the SBP group (31 cases) treated with SBP plus routine treatment and the control group (10 cases) with routine treatment only. Both were treated for 6 months. The changes of carotid atheromatous plaque (CAP), C reactive protein (CRP), fibrinogen (FIB), D-dimer and blood lipids, etc. were observed. Results After treatment, average number, total scores and area of plaque, as well as levels of CRP, FIB and D-dimer decreased significantly in the SBP group (P<0.05 or P<0.01), and were lower than those in the control group after treatment respectively (P<0.05). No severe adverse reaction occurred in both groups. ConclusionSBP is a safe and effective remedy for treatment of CAS.