冠心病患者血清oxLDL-Ab与hs-CRP含量的变化与相关性研究

目的:探讨冠心病(CoronaryHeartDisease,CHD)患者血清氧化型低密度脂蛋白自身抗体(anti-oxidizedLDLAutoantibodies,oxLDL-Ab)和高敏C-反应蛋白(High-SensitivityC-reactiveProtein,hs-CRP)水平的变化及其相互关系。方法:采用RIA分析法和免疫比浊法对152例CHD患者及90例健康成人血清中的oxLDL-IgG、oxLDL-IgM和hs-CRP的含量变化进行观察,并作相关性分析。结果:CHD患者血清oxLDL-IgG、oxLDL-IgM和hs-CRP含量均明显升高,与健康对照组相比差异均有显著的统计学意义(6.46±3.70)g/L、(2.65±0.83)g/L和(5.28±1.25)mg/Lvs(3.19±0.92)g/L、(0.82±0.27)g/L和(1.74±0.41)mg/L,P<0.01];CHD患者及健康成人血清hs-CRP与oxLDL-IgG和oxLDL-IgM之间无明显相关性(r=-0.113~0.102,P>0.05)。结论:oxLDL-Ab和hs-CRP与CHD的发生发展密切相关,且二者在冠状动脉硬化进程中可能各自扮演着重要的角色。

Changes of Serum oxLDL-Ab and hs-CRP Levels and Their Relationship in Patients with Coronary Heart Disease

Objective To investigate the changes of serum anti-oxidized LDL autoantibodies(oxLDL-Ab)and high-sensitivity C-reactive protein(hs-CRP) and their relationship in patients with coronary heart disease (CHD).Methods Serum samples were taken from 152 patients with CHD and 90.healthy subjects.The serum levels of oxLDL-IgG、oxLDL-IgM and hs-CRP were quantitatively measured by radioimmunoassay and immunonephelometry assay.Results The serum levels of oxLDL-IgG、oxLDL-IgM and hs-CRP were greatly elevated in patients with CHD as compared with healthy subjects (6.46±3.70)g/L、(2.65±0.83)g/L and (5.28±1.25)mg/L vs (3.19±0.92)g/L、(0.82±0.27)g/L and (1.74±0.41) mg/L,P<0.01)]. There was no significant correlation between the serum level of oxLDL-Ab including oxLDL-IgG and oxLDL-IgM and the serum level of hs-CRP in patients with CHD and healthy subjects(r=-0.113～0.102,P>0.05).Conclusion oxLDL-Ab and hs-CRP were closely correlated with the formation of CHD and they both maybe independently played important roles in the process of development of atherosclerosis.