奥曲肽联合腹水超滤浓缩回输治疗肝炎肝硬化晚期顽固性腹水的临床应用研究

目的：评价奥曲肽联合腹水浓缩回输治疗肝炎肝硬化晚期难治性腹水的疗效。方法：将84例肝硬化晚期顽固性腹水患者随机分为两组，研究组42例，常规治疗基础上加用奥曲肽联合腹水超滤浓缩回输腹腔治疗；对照42例，常规治疗基础上，采用治疗性腹腔穿刺放腹水治疗。疗程均为4用。结果：研究组治疗后体重、腹围、24h尿量、血浆及腹水中蛋白量及肌酐改善情况明显好于对照组（P〈0．05）。研究组临床疗效显著好于对照组（P〈0．05）。结论：奥曲肽联合腹水超滤浓缩回输腹腔技术是治疗肝炎肝硬化终末期顽固性腹水的一种较理想的治疗方法，因其价廉、易操作、疗效好特点值得临床应用推广。

Clinical Application Study of Octreotide Combined with Ascites Ultrafiltration Concentration Back- transfusion Treatment for Advanced Hepatitis Cirrhosis Refractory Ascites

Objective ：To evaluate the clinical efficacy of Octreotide combined with ascites ultrafiltration concentration back - transfusion into abdominal cavity treatment for posthepatitc cirrhosis complicating refractory ascites. Methods： 84 patients with posthepatitc cirrhosis complicating refractory ascites were randomly divided into study group and control group. Patients in both groups received conventional therapy for 4 weeks , Patients in study group received octreotide combined with the ascites ultrafiltration concentration back -transfusion into abdominal cavity concomitantly, while pa- tiens in control group received abdominal paracentesis apocenosis. Results： After treatment, abdominal perimeter, weight, urine volume for 24 h, serum albumin level, serum creatinine level in study group were better than that in control group （P 〈 0. 05 ）, The clinical efficacy of study group was better than that of control group（ P 〈 0. 05 ） o Conclusions： Octreotide combined with ascites reinfusion ultrafiltration technique of laparoscopic treatment of end - stage hepatitis cirrhosis is a better method of treatment of refractory ascites, because of its cheap and easy to operate, clinical application effect of good features is worth promoting.