中医分型治疗慢性再生障碍性贫血临床研究

目的:探讨再造生血颗粒治疗慢性再生障碍性贫血(CAA)肾阴虚型和肾阳虚型患者的临床疗效和作用机理.方法:选取慢性再障患者40例,其中肾阴虚型22例,肾阳虚型18例.均口服再造生血颗粒0.5 a.检测治疗前后骨髓CD34 细胞bcl-2、bax蛋白的表达.结果:治疗后肾阳虚型基本治愈9例,缓解6例,明显进步2例,无效1例,有效率为90.9%.肾阳虚型分别为5例、5例、8例、4例,有效率为81.8%.两组比较,P＜0.05.肾阳虚型患者的疗效明显优于肾阴虚型者.结论:肾阳虚型治疗前bcl-2值明显高于肾阴虚型,bax则相反.

The Clinical Study of Chinese Medicine Typing to Treating Chronic Aplastic Anemia

Objective: to approach the clinical effect and mechanism of reconstruction hemogenesis granules on treating chronic aplastic anemia of deficiency of kidney-yin and deficiency of kidney-yang.Method: 40 cases with chronic aplastic anemia(deficiency of kidney-yin is 22 cases and deficiency of kidney-yang is 18 cases) were treated with reconstruction hemogenesis granules on 6 months.marrow CD34 cell bcl-2 and bax express were detected before and after treatment.Result: elementary curing is 9 cases,anesis is 6 cases,obviously improvement is 2 cases and ineffective is 1 case in deficiency of kidney-yang.The effective power is 90.9%;elementary curing is 5 cases,anesis is 5 cases,obviously improvement is 8cases and ineffective is 4 cases in deficiency of kidney-yin.The effective power is 81.8%.the curative effect is better in deficiency of kidney-yang than deficiency of kidney-yin.Conclusion: bcl-2 value is higher in deficiency of kidney-yang than deficiency of kidney-yin before treatment and bax is opposite.