首乌藤的化学成分

目的分离和鉴定首乌藤中的化学成分。方法利用硅胶柱色谱、Sephadex LH-20柱色谱法等进行分离纯化,并通过理化常数测定和光谱分析鉴定了其化学结构。结果分离得到9个化合物,分别鉴定为:大黄素甲醚(physcion,1)、大黄素-8-甲醚(questin,2)、2,5-二甲基-7-羟基色原酮(2,5-dimethyl-7-hydroxychromone,3)、大黄素(emodin,4)、儿茶素(catechin,5)、大黄素甲醚-8-O-β-D-葡萄糖苷(physcion-8-O-β-D-glucopyranoside,6)、决明蒽酮-8-O-β-D-葡糖苷(torachrysone-8-O-β-D-glucopyranoside,7)、大黄素甲醚-8-O-β-D-葡萄糖苷(emodin-8-O-β-D-glucopyranoside,8)、2,3,5,4′-四羟基二苯乙烯-2-O-β-D-葡萄糖苷(2,3,5,4′-tetrahydroxystil-bene-2-O-β-D-glucopyranoside,9)。结论化合物3、7为该种植物中首次分离得到的化合物。

Chemical cnstituents of Caulis Polygoni Multiflori the stem of Polygonum multiflorum Thunb.

Objective To investigate chemical constituents of Caulis polygoni multiflori. Methods Multi-chromatographic methods were used for the isolation and purification. Structures were elucidated on the basis of chemical evidences and spectroscopic data analysis. Results Nine compounds were isolated from Caulis polygoni multiflori and identified as physcion (1), questin (2), 2,5-dimethyl-7-hydroxychromone (3), emodin (4), catechin (5), physcion-8-O-β-D-glucopyranoside (6), torachrysone-8-O-β-D-glucopyranoside (7), emodin-8-O-β-D-glucopyranoside (8), 2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucopyranoside (9). Conclusions Compounds 3 and 7 are isolated from Caulis polygoni multiflori for the first time.