血管回声跟踪技术评价辛伐他汀对高脂喂养兔血管弹性的影响

目的 探讨血管回声跟踪技术评价辛伐他汀干预高脂喂养兔血管弹性的效果.方法 27只兔随机分成3组:正常对照组(A组)、高脂喂养组(B组)、高脂+辛伐他汀组(C组),各组分别于喂养第4周、第8周末超声检测腹主动脉(AO)及股动脉(FA)弹性,8周末处死兔并截取动脉,免疫组化法检测诱导型一氧化氮合酶(iNOS)蛋白表达.结果 B组兔于喂养第4周时FA僵硬度(β)、弹性系数(Ep)、脉搏波传导速度(PWVβ)值较A组升高,顺应性(AC)值较A组减低,差异有统计学意义(P＜0.05);AO于喂养第8周时β、Ep、PWVβ值较A组升高,AC值较A组减低,差异有统计学意义(P＜0.05).C组兔于喂养第8周时FAβ、Ep、PWVβ值较B组减低,AC值较B组升高,差异有统计学意义(P＜0.05),AO各指标与B组比较差异无统计学意义.结论 短期服用辛伐他汀能提高兔FA的血管弹性,AO则无明显改变.

Evaluation of effects of simvastatin on vascular elasticity in fat-fed rabbits by echo-tracking technique

Objective To evaluate the effects of simvastatin on the vascular elasticitv in fat-fed rabbits by echo-tracking(ET)technique.Methods Twenty seven rabbits were divided randomly into 3 groups:normal control group(group A),high fat diet group(group B),simvastatin group(group C:high fat diet for the 1st 4 weeks and high fat diet+simvastatin for the 2nd 4 weeks).β,EP,AC,and PWVβof abdominal aorta (AO) and femoral artery(FA)of rabbits in group A、B、C were measured by ET technique at the end of 4th week and 8th week respectively.The expression of iNOS was measured at the end of 8th week.Results At the end of the 4th week,β,Ep,and PWVβ of FA were significantly inereased and AC was significantly decreased in group B compared to those in group A(P＜0.05).At the end of the 8th week,β,Ep,PWVβof AO were significantly increased and AC was significantly decreased in group B compared to those in group A(P＜0.05);β,Ep,PWVβ of FA were statistically decreased and AC was statistically increased in group C compared to those in group B(P＜0.05),however there was no significant difference of AO between groups B and C.Conclusions Short-term administration of simvastatin can improve the elasticity of some muscular arteries such as FA but not AO.