大鼠慢性压力后负荷心肌肥厚—心力衰竭模型的建立

目的：建立大鼠心肌肥厚－心力衰竭模型，深入心衰机制的研究。方法：缩窄幼年Wistar大鼠升主动脉，缓慢增加左心室压力后负荷，建立心肌肥厚－心力衰竭模型，并随机分为升主动脉缩窄组和同期假手术组，观察术后不同时期大鼠临床表现、尾动脉血压、体重、器官重量、心脏超声和血液动力学参数的变化。结果：手术成活率87％，缩窄术后4周出现心肌肥厚，12周明显肥厚，20周出现失代偿性心力衰竭。结论：此方法有效且重复性好，可较理想地模拟慢性压力后负荷心肌肥厚－心力衰竭的转变，对心衰机制的研究有重要价值。

Left Ventricular Hypertrophy to Heart Failure in Gradually Pressure Afterload Heart of Wistar Rat

Objective:Our purpose was to establish an ideal chronic pressure afterload heart failure rat model which has the transition from cardiac hypertrophy to heart failure. Methods: Chronic pressure afterload heart failure rat model was induced by gradually constricting the ascending aorta of young rats. Young rats were randomly divided into 2 groups: the constricted and sham operated groups. Clinical manifestation, tail cuff blood pressure, organ weight, and hemodynamic data were observed at various time after operation. Results: The overall survival rate was 87%. Tail cuff pressure began to increase in 4 weeks after operation. Left ventricular hypertrophy appeared in 12 weeks and heart failure in 5 months. Conclusion:It's a practical and reproducible model of cardiac hypertrophy that progresses to chronic heart failure.