| 草酸依地普仑片人体药动学研究 |
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| 引用本文： | 杨婵娟,温预关,王旭荣,马崔,温国林. 草酸依地普仑片人体药动学研究[J]. 中国药房, 2005, 16(12): 921-923 |
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| 作者姓名： | 杨婵娟 温预关 王旭荣 马崔 温国林 |
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| 作者单位： | 1. 广州市脑科医院,广州市,510370
2. 北京艾斯克医药技术开发有限公司,北京市,100012 |
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| 摘 要： | 目的:研究国产草酸依地普仑片在人体内的药动学。方法:10名健康志愿者单剂量口服30mg草酸依地普仑片,采用高效液相色谱法测定其血浆中草酸依地普仑浓度,药动学参数采用3p97软件进行拟合。结果:草酸依地普仑片药-时曲线符合二室模型,其Cmax、tmax、t1/2、AUC0～132、AUC0～∞分别为(42.73±10.19)μg/L、(2.90±0.32)h、(35.34±7.78)h、(1241.5±194.3)(μg·h)/L、(1327.5±210.5)(μg·h)/L。结论:该药动学研究结果可为临床用药提供参考。
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| 关 键 词： | 草酸依地普仑片 高效液相色谱法 药动学 |
| 文章编号： | 1001-0408(2005)12-0921-03 |
| 修稿时间： | 2004-08-27 |
Study on Pharmacokinetics of Escitalopram Oxalate Tablets in Human Body |
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| Yang Chanjuan,WEN Yuguan,WANG Xurong,MA Cui,WEN Guolin. Study on Pharmacokinetics of Escitalopram Oxalate Tablets in Human Body[J]. China Pharmacy, 2005, 16(12): 921-923 |
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| Authors: | Yang Chanjuan WEN Yuguan WANG Xurong MA Cui WEN Guolin |
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| Abstract: | OBJECTIVE:To study the pharmacokinetics of escitalopram oxalate tablets in human body.METHODS:Es-citalopram oxalate tablets were administered orally at a single dose of30mg to10healthy subjects respectively,the plasma concentration of escitalopram oxalate was determined by HPLC method,the pharmacokinetic parameter was fitted with3p97software.RESULTS:The concentration-time curve of escitalopram oxalate tablets was in line with the two-compartment model,the main pharmacokinetics parameters of escitalopram oxalate were as follows,the C max was(42.73±10.19)μg·L,t max was(2.90±0.32)h,t 1/2 was(35.34±7.78)h,AUC 0～132 was(1241.5±194.3)(μg·h)/L and the AUC 0～∞ was(1327.5±210.5)(μg·h)/L.CONCLUSION:The study on pharmacokinetics can be used as a reference in the clinical medication. |
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| Keywords: | Escitalopram oxalate tablet HPLC Pharmacokinetics |
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