负荷后1小时血糖与老年男性高血压患者颈动脉内中膜厚度的相关性

目的 探讨口服葡萄糖耐量试验(OGTT)1 h血糖(1 hPG)升高与老年男性原发性高血压患者动脉硬化的相关性.方法 将126例老年男性原发性高血压患者根据OGTT结果分为1hPG正常的正常糖耐量组、1 hPG升高组、糖耐量异常组和糖尿病组,比较不同组间各代谢指标及颈动脉内中膜厚度(IMT).结果 1 hPG升高组1 hPG(12.0±1.1)mmol/L与糖尿量异常组(11.1±1.8)mmol/l,相似,高于正常糖耐量组(9.1±1.4)mmol/L(P<0.01),低于糖尿病组(P<0.01);IMT值在4组内递增(P<0.05),1 hPG升高组IMT值为(1.02±0.12)mm;1 hPG为颈动脉IMT的独立相关因素(P<0.01).结论 男性高血压人群1 hPG升高较糖耐量异常更早出现,与动脉硬化相关.

The correlation study of 1-hour postload plasma glucose level and carotid intima-media thickness in elderly male patients with hypertension

Objective To observe the correlation between 1-hour postload plasma glucose and carotid intima-media thickness (IMT) in elderly male patients with hypertension.Methods One hundred and twenty six elderly male patients with hypertension were enrolled and divided into four groups: normal glucose tolerance with normal 1 h plasma glucose (1 hPG) group (low-NGT, n=42); normal glucose tolerance with high lh plasma glucose group (high-NGT, n=23);impaired glucose tolerance group (IGT, n=27) and diabetic group (n=84). The differences of blood pressure, blood glucose, blood lipid and intimia-media thickness among groups were analyzed.Results OGTT 1 hPG in high-NGT group was similar with IGT group[(12.0±1.1)mmol/L vs. (11.1±1.8)mrnol/L, P>0. 053 ,but significantly higher than that in Iow-NGT group ((12.0±1.1)mmol/L vs. (9. 1±1.4) mmol/L, P<0.01]. The value of IMT was gradually increased in four groups (P<0.05) and it was (1.02±0. 12) mm in high-NGT group. OGTT 1 hPG was the independent risk factor for IMT(P< 0.01).Conclusions OC-TT 1h plasma glucose is associated with atherosclerosis in elderly male hypertensive people.