高频条件下(7 MHz)SonoVue与Sonazoid剂量变化对兔肝造影效能的比较

目的 比较高频条件下（7 MHz）不同剂量的两种超声造影剂SonoVue和Sonazoid的显影效果。方法 在相同发射频率（7 MHz）和机械指数（SonoVue为0.25, Sonazoid为0.40）下，分别对8只新西兰大白兔多次团注不同剂量的SonoVue及Sonazoid，应用时间-强度曲线做定量分析，并统计兔肝增强的灌注参数与造影剂剂量的相关性。结果 SonoVue组随着造影剂剂量的增加，其时间-强度曲线的上升时间（RT）、达峰时间（TTP）、平均通过时间（mTT）未见明显变化，其峰值强度（PI）于SonoVue剂量为0.18 mL/kg时达最大值。Sonazoid组mTT随着造影剂剂量的增加而浮动；RT、TTP在Sonazoid剂量为0.015、0.03 mL/kg时为最高值（R²=0.39），且随着造影剂剂量的增加呈下降趋势；PI随着造影剂剂量的增加而逐渐增加。结论 SonoVue和Sonazoid的理化特性不同，在高频条件下（7 MHz）其超声造影效能各不相同。

Comparison of the dose changes of SonoVue and Sonazoid to imaging effect of rabbit liver in the high-frequency(7 MHz) state

Objective Contrast enhancement of SonoVue and Sonazoid were compared in rabbit liver at frequency of 7 MHz by ultrasound using an imaging dose ranging from 0.015 to 0.24 mL/kg.Method Eight rabbits（weight 2.30±0.30 kg） were injected with the two contrast agents in 7-8 dosage bolus level.Quantitative analysis was done by using time-intensity curve（TIC） to correlate the concentration of the agents and perfusion parameters.Result With the same frequency and a mechanical index was adapted for each agent（mechanical index is 0.25 for SonoVue and 0.4 for Sonazoid）：（1） SonoVue group：rise time（RT）,time to peak（TTP） and mean transit time（mTT） did not change significantly along with an increase of dose;at 0.18 mL/kg,peak intensity（PI） reached to maximum.（2） Sonazoid group：RT and TTP climbed to peak（0.015mL/kg,0.03 mL/kg） along with an increase of dose and mTT varied significantly with imaging dose.PI increased with the dose.Conclusion Due to the different physical and chemical properties,the two ultrasonic contrast agents have different imaging effects in the high-frequency（7 MHz） state.