The effect of a new 9-aminoacridine derivative on working and long-term memory in rats

The effects of Vp, a new 9-aminoacridine derivative, on the radial maze performance of intact and scopolamine-treated rats were compared with those of amiridin and tacrine. In intact rats Vp improved the formation of long-term spatial memory and has a positive effect on working memory at the initial stage of training. In scopolamine-treated rats Vp reduced the amnesic effects of scopolamine on both kinds of memory. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 2, pp. 202–204, February 1999