Therapy-related acute leukemia with mixed phenotype and t(9;22)(q32;q11.2): a case report and review of the literature |
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Authors: | Cho Jin-Hee Hur Mina Moon Hee-Won Yun Yeo-Min Ko Young Sin Kim Wan Seop Lee Mark Hong |
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Institution: | a Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul 143-729, Koreab Department of Pathology, Konkuk University School of Medicine, Seoul 143-729, Koreac Department of Internal Medicine, Konkuk University School of Medicine, Seoul 143-729, Korea |
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Abstract: | Therapy-related acute leukemia showing mixed phenotype is extremely rare. We report a 49-year-old woman who presented with palpable masses in her neck and back. She had received systemic chemotherapy (adriamycin and cisplatin) and radiotherapy for endometrial adenocarcinoma 7 years before. Her peripheral blood and bone marrow showed increased blasts, which coexpressed myeloid (CD13, CD33, and myeloperoxidase) and B-lymphoid antigens (CD19 and CD79a). Cytogenetic analysis showed a karyotype of 46,XX,dup(1)(q21q32),add(5)(q33),t(9;22)(q34;q11.2)12]/47,idem,+der(22)t(9;22)8], and BCR/ABL1 rearrangement was detected. Leukemic infiltration was also confirmed in her back mass. After induction chemotherapy with idarubicin, cytarabine, and imatinib, she achieved complete remission. Only 2 cases of therapy-related acute leukemia with mixed phenotype have been reported so far: one with hyperploidy and the other with t(1;21)(p36;q22). To the best of our knowledge, this is the first case of therapy-related acute leukemia with mixed phenotype and t(9;22) as well as extramedullary leukemic infiltrations. |
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Keywords: | Therapy Mixed phenotype Acute leukemia t(9 22) |
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