Pathogenesis of neuroimmunologic diseases |
| |
Authors: | C S Constantinescu B Milliard T Fujioka M K Bhopale D Calida Dr A M Rostami |
| |
Institution: | (1) Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, 19104 Philadelphia, PA |
| |
Abstract: | Animal models of autoimmune diseases have greatly improved our current understanding of the pathogenesis of human autoimmunity
and have provided the potential for therapies based on manipulation of the immune system. In our laboratory, we have investigated
the immunopathogenesis of autoimmune diseases of the nervous system and muscle. We have developed immune-based approaches
for the suppression of experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), and experimental
autoimmune neuritis (EAN), a model for the Guillain-Barré syndrome (GBS). These approaches included induction of peripheral
tolerance, immunotoxin targeting of activated T cells, and cytokine manipulations. In addition, we identified the antigen
and characterized immunopathologically an autoimmune inflammatory disease of skeletal muscle, experimental autoimmune myositis
(EAM), a model for the human inflammatory muscle disease polymyositis. |
| |
Keywords: | Multiple sclerosis Experimental autoimmune encephalomyelitis Guillain-Barré syndrome Experimental autoimmune neuritis Polymyositis Experimental autoimmune myositis |
本文献已被 SpringerLink 等数据库收录! |
|