| 黄芪皂甙及补中益气复方对重症肌无力体外合成烟碱型乙酰胆碱受体抗体的调节作用 |
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| 引用本文： | 涂来慧,黄德仁,张仁琴,沈茜,余友渔,洪永福,李庚和.黄芪皂甙及补中益气复方对重症肌无力体外合成烟碱型乙酰胆碱受体抗体的调节作用[J].第二军医大学学报,1992(3). |
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| 作者姓名： | 涂来慧 黄德仁 张仁琴 沈茜 余友渔 洪永福 李庚和 |
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| 作者单位： | 长海医院神经科 200433
(涂来慧，黄德仁，张仁琴)，长海医院临床实验科 200433
(沈茜)，长海医院放疗中心 200433
(余友渔)，第二军医大学药学院中西药研究室 200433
(洪永福)，上海市虹口区中心医院中医科 200082(李庚和) |
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| 摘 要： | 按重症肌无力脾虚辨证理论,根据多年临床冶疗经验,选用黄芪皂甙及补中益气复方制剂(即强力冲剂)对10例重症肌无力(MG)患者14例次周围血单个核细胞培养作药物实验,并与地塞米松,~(60)Co照射对照。结果提示水溶性黄芪皂甙使培养上清液中烟碱型乙酰胆碱受体抗体滴度明显降低(6例由418.8～2328fmol/ml降为0fmol/ml,2例由1143～1235fmol/ml降为43～157fmol/ml)。补中益气复方有增强黄芪皂甙单剂的免设调节作用。
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| 关 键 词： | 黄芪 皂甙类 重症肌无力 受体 胆碱能 医学 中国传统 人类 |
Regulatory Action of Astragalus Saponins and Buzhong Yiqi Compound on Synthesis of Nicotinic Acetylcholine Receptor Antibody in Vitro for Myasthenia Gravis |
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| Tu Lalhui,Huang Deren,Ztiang Renqin,Shen Qian,Yu Youyu,Hong Yongju,Li Genghe.Regulatory Action of Astragalus Saponins and Buzhong Yiqi Compound on Synthesis of Nicotinic Acetylcholine Receptor Antibody in Vitro for Myasthenia Gravis[J].Academic Journal of Second Military Medical University,1992(3). |
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| Authors: | Tu Lalhui Huang Deren Ztiang Renqin Shen Qian Yu Youyu Hong Yongju Li Genghe |
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| Abstract: | According to the differentiation of symptamcomplex theory of Spleen Deficiency on myasthenia grvis, with our clinical experience of treatment for some years. Astragalus Saponins and Buzhong Yiqi compound were selected to make phannaceutic experiment for peripheral blood mononuclear cells culture of 14 samples of 10 myasthenia gravis patients. Two controlled groups were given with the treatment of dexamethasone and 60Co respectively. The results showed that liters of nAchR-Ab in cells culture superatants were significantly decreased by watersoluble Astragalus saponias (418.8-2328 fmol/rnl- 0 fmol/ml in 6 cases; 1143 -1235 fmol/ml - 43-157 fmol/ml in 2 cases). Buzhong Yiqi compund could enhance the immunoregulatory action. |
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| Keywords: | Astragalus membranaceus saponins myasthenia gravis receptors eholinergic medicine Chinese traditional human |
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