| 中脑中缝核和5-HT在电针抑制cAMP诱发的家兔皮层痫样电活动中的作用 |
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| 引用本文： | 娄之聪,陈水村. 中脑中缝核和5-HT在电针抑制cAMP诱发的家兔皮层痫样电活动中的作用[J]. 南方医科大学学报, 1991, 0(3) |
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| 作者姓名： | 娄之聪 陈水村 |
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| 作者单位： | 第一军医大学生理学教研室(娄之聪)，第一军医大学生理学教研室(陈水村) |
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| 摘 要： | 本实验观察到电针对cAMP所诱发的家兔皮层痫样电活动的抑制作用,可被赛庚啶、电解损毁中脑中缝核所消除或减弱;电刺激中脑中缝核则有与电针抑痛相似的效应;提示中缝核的5—HT能神经元可能参与电针抑痫效应。
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| 关 键 词： | 痫波 皮层电图 环磷酸腺苷 电针 中缝核 赛庚啶 |
The action of Nu . raphe and 5-HT in the inhibitory effect of electroacupuncture on cAMP induced ECoG epileptiform waves |
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| Lou Zhicong and Chen Shuicun. The action of Nu . raphe and 5-HT in the inhibitory effect of electroacupuncture on cAMP induced ECoG epileptiform waves[J]. Journal of Southern Medical University, 1991, 0(3) |
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| Authors: | Lou Zhicong and Chen Shuicun |
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| Affiliation: | Lou Zhicong and Chen Shuicun Department of Physiology |
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| Abstract: | The fact that application of electro-acupuncture on bilateral Zushanli Points inhibits epileptic seizure waves in ECoG of conscious rabbits was found in ourp revious experiments. In the present work we found that electric stimulation of Nu raphe decreased significantly the frequency .amplitude and duration of the epilep-tiform discharges. This effect showed no significant difference in comparison with that in the electroacupuncture group. The inhibitory effect of electroacupuncture was abolished or markedly decreased after destruction ( by electrolysis ) of Nu raphe or after cyproheptadine iv injection. These results suggested that 5-HT-nergic neurons in Nu raphe may play an important role in the inhibitory effect of electroacupuncture on the generation of c-AMP induced ECoG epilaptiform waves. |
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| Keywords: | epileptic waves ECoG c-AMP electroacupuncture Nu raphe cyproheptadine |
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