4种肿瘤标志物联合检测对乳腺癌的诊断价值

目的探讨血清肿瘤标志物CA153、CA125、CA199、CEA联合检测对乳腺癌早期诊断的价值。方法采用化学发光法分别检测乳腺癌和乳腺良性疾病患者血清中CA153、CA125、CA199、CEA的水平。结果 CA153、CA125、CA199、CEA 4种肿瘤标志物联合检测乳腺癌患者与单独检测相比灵敏度明显提高(均P0.01)。结论联合检测乳腺癌患者血清标志物CA153、CA125、CA199、CEA的阳性率、敏感性有较大幅度的提高,四项肿瘤标志物的联合检测虽不能作为乳腺癌的特异性指标,但可为临床早期发现、诊断乳腺癌提供十分重要的依据。

Diagnostic value of combination detection of 4 tumor markers on breast cancer

Objective To investigate the value of serum CA153,CA125,CA199 and CEA combined detection on early diagnosis of breast cancer.Methods Serum CA153,CA125,CA199 and CEA levels in the patients with benign breast diseases and breast cancer were detected by chemiluminescence.Results The sensitivity of the combined detection of 4 tumor markers CA153,CA125,CA199 and CEA in breast cancer was obviously higher than that of the single detection（all P0.01）.Conclusion The positive rate and sensitivity of the combined detection of serum markers CA153,CA125,CA199 and CEA in the patients with breast cancer will be increased by a large margin.Although the combined detection of 4 tumor markers is not as the specific indicator of breasr cancer,but it could provide more important basis for its early detection and diagnosis in clinic.