Anti-Helicobacter pylori activity of quinolone alkaloids from Evodiae fructus. |
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| Authors: | T C Rho E A Bae D H Kim W K Oh B Y Kim J S Ahn H S Lee |
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| Institution: | Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon. |
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| Abstract: | A biologically monitored fractionation of methanol extract of the fruit of Evodia rutaecarpa led to the isolation of six quinolone alkaloids, evocarpine (1), 1-methyl-2-(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (2), 1-methyl-2-(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolo ne (3), 1-methyl-2-undecyl-4(1H)-quinolone (4), dihydroevocarpine (5), 1-methyl-2-pentadecyl-4(1H)-quinolone (6). They showed potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. However, they had no effect on Helicobacter pylori urease activity at the concentration of 300 microg/ml. |
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