Effect of diltiazem on kidney function during laparoscopic surgery |
| |
Authors: | Ji Young Kim Kyung Cheon Lee Hong Soon Kim Youn Yi Jo Hyun Jeong Kwak |
| |
Institution: | (1) Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea;(2) Department of Anesthesiology and Pain Medicine, Gachon University of Medicine and Science Gil Medical Center, 1198 Guwol-dong, Namdong-gu, Incheon, 405-760, Korea |
| |
Abstract: | Background Pneumoperitoneum is known to be associated with transient impairment in kidney function. This study was designed to investigate
the effect of diltiazem on acute kidney injury during positive pneumoperitoneum in patients undergoing laparoscopic surgery.
Methods Thirty-two patients of American Society of Anesthesiologists (ASA) 1 and 2 physical status undergoing laparoscopic surgery
were randomly divided into control (normal saline infusion) and diltiazem groups (diltiazem 2 μg/kg/min). Urinary flow, urinary
sodium excretion, creatinine clearance (CrCl), and hemodynamic variables were determined during pneumoperitoneum and at postoperative
2 h. CrCl using Cockcroft–Gault equation was calculated before surgery (baseline), and at postoperative days 1 (POD1) and
2.
Results The hemodynamic parameters were similar in both groups. CrCl during pneumoperitoneum in the diltiazem group was significantly
higher than that in the control group (90.8 ± 49.0 ml/min/1.73 m2 vs. 54.2 ± 31.6 ml/min/1.73 m2) (P = 0.026). CrCl calculated with Cockcroft–Gault equation was similar in both groups at baseline, POD1, and POD2. Urinary flow
was significantly increased in both groups at postoperative 2 h compared with that during pneumoperitoneum.
Conclusion Continuous infusion of diltiazem 2 μg/kg/min prevented the decrease in CrCl during pneumoperitoneum without hemodynamic derangement.
Although the decrease in CrCl was transient in patients with normal kidney function in this study, diltiazem may be used to
prevent further kidney injury in those with elevated CrCl during laparoscopic surgery. |
| |
Keywords: | Pneumoperitoneum Diltiazem Kidney function |
本文献已被 SpringerLink 等数据库收录! |
|