The use of conformationally thermostabilised GPCRs in drug discovery: application to fragment,structure and biophysical techniques |
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| Affiliation: | 1. Centre for Human Drug Research, Leiden, The Netherlands;2. Research and Development Department, H. Lundbeck A/S, Valby, Denmark;3. Leiden University Medical Centre, Leiden, The Netherlands;4. Janssen Research & Development, LLC, Johnson & Johnson, United States;5. Lilly Research Laboratories, Eli Lilly and Co, Windlesham, UK;6. Heptares Therapeutics Ltd, Cambridge, UK;7. Department of Psychiatry, University of Cambridge, Cambridge, UK;8. European Medicines Agency (EMA), 30 Churchill Place, Canary Wharf, London, UK;9. Department of Psychiatry, University of Texas, Southwestern Medical School, Dallas, TX, United States;10. Faculty of Science and Engineering, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands |
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