Executive function and health-related quality of life in pediatric epilepsy |
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| Affiliation: | 1. Comprehensive Epilepsy Program, Dell Children''s Medical Center of Central Texas, Austin, TX, USA;2. Department of Educational Psychology, The University of Texas at Austin, Austin, TX, USA;3. Department of Psychology, The University of Texas at Austin, Austin, TX, USA;1. Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China;2. Department of Neurology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China;3. Guangxi Technological College of Machinery and Electricity, Nanning, 530007, China;1. University Children''s Hospital Heidelberg, Section Neuropediatrics and Inborn Errors of Metabolism, Heidelberg, Germany;2. Department of Neuropediatrics, University Medical Center Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany;3. Department of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany;4. Department of Pediatric Neurology, Goethe University Hospital, Frankfurt, Germany;1. Department of Pediatrics, McMaster University and McMaster Children''s Hospital, Hamilton, ON, Canada;2. Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada |
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| Abstract: | Children and adolescents with epilepsy often show higher rates of executive functioning deficits and are at an increased risk of diminished health-related quality of life (HRQOL). The purpose of the current study was to determine the extent to which executive dysfunction predicts HRQOL in youth with epilepsy. Data included parental ratings on the Behavior Rating Inventory of Executive Function (BRIEF) and the Quality of Life in Childhood Epilepsy (QOLCE) questionnaire for 130 children and adolescents with epilepsy (mean age = 11 years, 6 months; SD = 3 years, 6 months). Our results identified executive dysfunction in nearly half of the sample (49%). Moderate-to-large correlations were identified between the BRIEF and the QOLCE subscales of well-being, cognition, and behavior. The working memory subscale on the BRIEF emerged as the sole significant predictor of HRQOL. These results underscore the significant role of executive function in pediatric epilepsy. Proactive screening for executive dysfunction to identify those at risk of poor HRQOL is merited, and these results bring to question the potential role of behavioral interventions to improve HRQOL in pediatric epilepsy by specifically treating and/or accommodating for executive deficits. |
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