Attention and executive functions in the early course of pediatric epilepsy |
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| Affiliation: | 1. University Children''s Hospital Heidelberg, Section Neuropediatrics and Inborn Errors of Metabolism, Heidelberg, Germany;2. Department of Neuropediatrics, University Medical Center Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany;3. Department of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany;4. Department of Pediatric Neurology, Goethe University Hospital, Frankfurt, Germany;1. Florida Institute of Technology, Department of Psychology, 150 W. University Blvd., Melbourne, FL 32901, USA;2. Florida Hospital for Children, Comprehensive Epilepsy Center, 615 E. Princeton St., Orlando, FL 32803, USA;3. Boston Children''s Hospital, Department of Neurology, Division of Epilepsy, 300 Longwood Ave., Fegan 9, Boston, MA 02115, USA;1. Saint Louis University, Department of Psychology, 3700 Lindell Blvd., St. Louis, MO 63108, United States;2. St. Louis Children''s Hospital, Department of Psychology, 1 Children''s Place, St. Louis, MO 63110, United States;1. Comprehensive Epilepsy Program, Dell Children''s Medical Center of Central Texas, Austin, TX, USA;2. Department of Educational Psychology, The University of Texas at Austin, Austin, TX, USA;3. Department of Psychology, The University of Texas at Austin, Austin, TX, USA |
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| Abstract: | ObjectiveOur prospective study aimed at exploring attention and executive functions in children with new-onset epilepsy prior to and during the early course of antiepileptic treatment. Sociodemographic and epilepsy-related factors were analyzed as potential predictors both of impaired cognitive functions as well as for changes in cognitive functioning in the early course of illness.MethodsFrom a total group of 115 children aged six to 17 years without major disabilities, 76 children were assessed longitudinally with a screening tool for attention and executive functions (EpiTrack Junior®). Sociodemographic variables (gender, age at epilepsy onset, need of special education) and epilepsy-related variables (etiology of epilepsy, semiology of seizures, number of seizures) were considered as potential predictors for impaired functions prior to treatment and for deterioration/amelioration in cognitive functions in the early course.ResultsAttention and executive functions of children with new-onset epilepsy were significantly more often impaired when compared with a healthy population, but less often when compared with children with chronic epilepsy. The majority of children showed stable cognitive functioning in the early course of treatment. The risk of impaired cognitive functions was significantly heightened when etiology of epilepsy was unknown or not classifiable. The chance for improvement of functioning was lowered by having a genetic epilepsy, or an unknown semiology of seizures.ConclusionsChildren with new-onset epilepsy are at high risk for impaired attention and executive functions even prior to antiepileptic treatment, especially when etiology of their epilepsy remains unclear. The high stability of cognitive functioning in the early course can be used in counseling of families who worry about negative side effects of drug treatment. Finally, a systematic assessment of cognitive functions in children with new-onset epilepsy is necessary to detect subtle deficits in the early course and adjust treatment accordingly. |
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