Psychoses in epilepsy: A comparison of postictal and interictal psychoses |
| |
| Affiliation: | 1. Department of Neurology, Medical University of Vienna, Austria;2. Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology, 2nd Neurological Department, General Hospital Hietzing with Neurological Center Rosenhuegel, Vienna, Austria;1. Shree Krishna Hospital, Karamsad, Anand, Gujarat, India;2. Dept. of Neuro-Medicine, Pramukhswami Medical College, Karamsad, Anand, Gujarat 388325, India;3. Dept. of Neurology, All India Institute of Medical Sciences, New Delhi 110029, India;4. Dept. of Psychiatry, All India Institute of Medical Sciences, New Delhi 110029, India;5. Dept. of Neurosurgery, All India Institute of Medical Sciences, New Delhi 110029, India;6. Dept. of Neuro-radiology, All India Institute of Medical Sciences, New Delhi 110029, India;7. Dept. of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India;1. Wake Forest School of Medicine, Department of Psychiatry, Winston-Salem, NC, United States;2. Yale School of Medicine, Department of Neurology, New Haven, CT, United States;3. Yale School of Medicine, Department of Psychiatry, New Haven, CT, United States;1. The School of Psychology, University of Sydney, Australia;2. Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia;3. University of Western Sydney, Centre for Health Research and School of Social Sciences and Psychology, Australia;4. Institute of Clinical Neurosciences, The Royal Prince Alfred Hospital, Sydney, Australia;5. Central Medical School, University of Sydney, Australia;6. Australian College for Applied Psychology, Australia;1. Department of Neurology, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg;2. Royal Hallamshire Hospital, Academic Neurology Unit, University of Sheffield, Sheffield, UK |
| |
| Abstract: | We retrospectively analyzed data of patients with epilepsy (n = 1434) evaluated with prolonged EEG monitoring in order to estimate the prevalence of postictal psychosis (PP) and interictal psychosis (IP), to investigate a potential association of psychosis subtype with epilepsy type, and to assess differences between PP and IP. The overall prevalence of psychosis was 5.9% (N = 85); prevalence of PP (N = 53) and IP (N = 32) was 3.7% and 2.2%, respectively. Of patients with psychosis, 97.6% had localization-related epilepsy (LRE). Prevalence of psychosis was highest (9.3%) in patients with temporal lobe epilepsy (TLE). When comparing PP with IP groups on demographic, clinical, and psychopathological variables, patients with IP were younger at occurrence of first psychosis (P = 0.048), had a shorter interval between epilepsy onset and first psychosis (P = 0.002), and more frequently exhibited schizophreniform traits (conceptual disorganization: P = 0.008; negative symptoms: P = 0.017) than those with PP. Postictal psychosis was significantly associated with a temporal seizure onset on ictal EEG (P = 0.000) and a higher incidence of violent behavior during psychosis (P = 0.047). To conclude, our results support the presumption of a preponderance of LRE in patients with psychosis and that of a specific association of TLE with psychosis, in particular with PP. Given the significant differences between groups, PP and IP may represent distinct clinical entities potentially with a different neurobiological background. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
